Bupropion is a pill you take to reduce your craving for tobacco. The way it does this is not entirely known. Bupropion does not contain nicotine and does not help you quit smoking in the same way that nicotine replacement therapy does. But like other medicines, it decreases cravings and withdrawal symptoms .
Are Zyban and Wellbutrin the Same Thing? Zyban (bupropion) and Wellbutrin (bupropion) are both forms of the antidepressant bupropion used for different purposes. Zyban is used for smoking cessation. Wellbutrin is used for the management of major depression and seasonal affective disorder.